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ARCHIVES OF THE BALKAN MEDICAL UNION

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With the development of science and technology, an increasing number of approaches have been emerging for repairing and regenerating the damaged organs, such as cell therapy, gene therapy and transplant etc. However, the side effects of these methods limit their clinical use.

For example, myoblast transplantation leads to an increase in number of hpv vaccine side effects cough postoperative arrhythmic events 1. Therefore, it has a long way to use these approaches for clinical therapy in a short-term and it is urgent to look for secure effective strategies.

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Recently, extracellular vesicles EVs have attracted extensive interests as a potential therapeutic strategy of diseases such as cancer, cardiovascular diseases etc. A growing number of investigations demonstrate that various engineered EVs can repair the damaged tissue in vivo 2.

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This editorial highlights 6 selected papers dedicated to the engineered extracellular vesicles as well as nanoparticles, including: 1 classical strategies for modifying EVs; 2 the roles of engineered EVs in treatment. Besides, the outlook for engineered EVs has been briefly discussed.

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To improve the efficiency of EVs as well as targeted tissue retention, several investigations were performed. This approach laid the foundation for cell and cardiac-specific EVs delivery, which gives a reference medicament pentru viermi pentru copil studying targeted-EV.

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Interestingly, Tang et al came up with a novel idea based on the recruitment of platelets by injured endothelial cells 4.

These authors decorated platelet-microvesicles inside of platelet, similar with EVs on the surface of cardiosphere-derived cardiac stem cells CSCswhich significantly increased the retention in the heart.

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This manipulation approach is safe and straightforward, which opens novel insights into targeted-EVs for therapy. Recently, Liming et al used an adhesive hydrogel to enhance the retention of EVs 5.

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The Exo-pGel presents a promising strategy for preclinical treatment. It has been well established that the engineered EVs have great potential for disease treatment in animal models.

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This work demonstrates a novel approach for increasing delivery of myocardial infarction treatment. Liu et al reported that EVs loading with novel complex hydrogels can promote wounds healing, which provides another effective hydrogel strategy for engineering EVs 7.

Li et al investigated the roles of Exo-pGel in treatment of spinal cord injury.

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The Exo-pGel significantly promoted nerve recovery via inhibiting oxidative stress and inflammation5. Besides, Chuanjiang He et al give an insight into hpv vaccine side effects cough EVs engineered as powerful tools in translational medicine 8.

Notably, more preclinical investigations and clinical trials are still needed to elucidate the possibility of engineered EVs and nanoparticles in human diseases treatment.

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